Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuropathological and transcriptomic characteristics of the aged brain

9 Nov 2017

Abstract excerpt

As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer's disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology and cognitive abilities with advancing age, indicative of individual variation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29120328
DOI: 10.7554/elife.31126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuropathological and transcriptomic characteristics of the aged brainPMID 29120328Read ↗

Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer’s disease and agingSemantic proximity Read ↗

Proteo-transcriptomic analysis reveals brain-region-specific gene and biomarker expression in post-mortem neural tissue of Alzheimer’s patientsSemantic proximity Read ↗

Transcriptomic changes highly similar to Alzheimer’s disease are observed in a subpopulation of individuals during normal brain agingSemantic proximity Read ↗

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseasesSemantic proximity Read ↗

Blood RNA transcripts reveal similar and differential alterations in fundamental cellular processes in Alzheimer's disease and other neurodegenerative diseasesSemantic proximity Read ↗

Proteomic Atlas of the Human Brain in Alzheimer’s DiseaseSemantic proximity Read ↗

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status.Semantic proximity Read ↗

Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s diseaseSemantic proximity Read ↗

Transcriptome Signatures for Cognitive Resilience Among Individuals with Pathologically Confirmed Alzheimer DiseaseSemantic proximity Read ↗

Molecular Insights into the Pathogenesis of Alzheimer's Disease and Its Relationship to Normal AgingSemantic proximity Read ↗

Multi-omics characterization of vascular, neurodegenerative, and mixed neuropathology in the aging human brainSemantic proximity Read ↗

Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.