Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s Disease

1 Jul 2019

Abstract excerpt

Asymptomatic and symptomatic Alzheimer's disease (AD) subjects may present with equivalent neuropathological burdens but have significantly different antemortem cognitive decline rates. Using the transcriptome as a proxy for functional state, we selected 414 expression profiles of symptomatic AD subjects and age-matched non-demented controls from a community-based neuropathological study. By combining brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Bioinformatics and Genomic Networks
Share to Computational Drug Discovery Methods

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31340147
DOI: 10.1016/j.celrep.2019.06.073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s DiseasePMID 31340147Read ↗

Perturbed functional networks in Alzheimer’s Disease reveal opposing roles for TGIF and EGR3Semantic proximity Read ↗

Systematic Analysis of Biological Processes Reveals Gene Co-expression Modules Driving Pathway Dysregulation in Alzheimer’s DiseaseSemantic proximity Read ↗

Hippocampal transcriptome profiling combined with protein-protein interaction analysis elucidates Alzheimer's disease pathways and genesSemantic proximity Read ↗

Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s diseaseSemantic proximity Read ↗

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.Semantic proximity Read ↗

A Gene Expression Profile of Alzheimer's DiseaseSemantic proximity Read ↗

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysisSemantic proximity Read ↗

Genes and pathways underlying regional and cell type changes in Alzheimer's diseaseSemantic proximity Read ↗

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.Semantic proximity Read ↗

Integrating the Alzheimer's Disease Proteome and Transcriptome: A Comprehensive Network Model of a Complex DiseaseSemantic proximity Read ↗

Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adultsSemantic proximity Read ↗

Transcriptomic analysis of human brains with Alzheimer’s disease reveals the altered expression of synaptic genes linked to cognitive deficitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.