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An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

17 Feb 2021

Abstract excerpt

v2.4, tightly binds S of SARS-associated viruses from humans and bats, despite the ACE2-binding surface being a region of high diversity. Saturation mutagenesis of the receptor-binding domain followed by in vitro selection, with wild-type ACE2 and the engineered decoy competing for binding sites, failed to find S mutants that discriminate in favor of the wild-type receptor. We conclude that resistance to...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 33597251
DOI: 10.1126/sciadv.abf1738

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