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Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo

7 Dec 2022

Abstract excerpt

As severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) evolves to escape natural antibodies, it also loses sensitivity to therapeutic antibody drugs. By contrast, evolution selects for binding to ACE2, the cell-surface receptor required for SARS-CoV-2 infection. Consistent with this, we find that an ACE2 decoy neutralizes antibody-resistant variants, including Omicron, with no loss in potency. To...

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PMID: 36475798
DOI: 10.1126/sciadv.abq6527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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