Article

Protein scaffold-based multimerization of soluble ACE2 efficiently blocks SARS-CoV-2 infection <i>in vitro</i> and <i>in vivo</i>

2021-01-06

Abstract excerpt

Soluble ACE2 (sACE2) decoy receptors are promising agents to inhibit SARS-CoV-2, as their efficiency is less likely to be affected by common escape mutations in viral proteins. However, their success may be limited by their relatively poor potency. To address this challenge, we developed a large decoy library of sACE2 fusion proteins, generated with several protease inhibitors or multimerization tags. Among these...

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Literature Corpus work: b8103d6a-ea6b-5792-bac7-b54da35db0fd
DOI: 10.1101/2021.01.04.425128

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