Article

High affinity modified ACE2 receptors protect from SARS-CoV-2 infection in hamsters

2020-09-16

Abstract excerpt

<h4>ABSTRACT</h4> The SARS-CoV-2 spike protein binds to the human angiotensin-converting enzyme 2 (ACE2) receptor via receptor binding domain (RBD) to enter into the cell and inhibiting this interaction is a main approach to inhibit SARS-CoV-2 infection. We engineered ACE2 to enhance the affinity with directed evolution in 293T cells. Three cycles of random mutation and cell sorting achieved 100-fold higher affin...

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Literature Corpus work: 3880a7a0-b04d-5f21-954f-60d742e58ecd
DOI: 10.1101/2020.09.16.299891

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