Article

Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic pathways, Inflammation, and Atherosclerosis

2022-07-05

Abstract excerpt

<h4>BACKGROUND</h4> Atherosclerosis is an inflammatory vascular disease marked by hyperlipidemia and hematopoietic stem cell (HSC) expansion. Activin A, a member of the Activin/GDF/TGFβ/BMP family is broadly expressed and increases in human atherosclerosis, but its functional effects in vivo in this context remain unclear. <h4>METHODS</h4> We studied LDLR -/- mice on a Western diet for 12 weeks and used adeno...

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Literature Corpus work: 4dd9fd62-b93b-5e2d-b1e9-b6d151f74299
DOI: 10.1101/2022.07.05.498830

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