Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AAV-mediated administration of myostatin pro-peptide mutant in adult Ldlr null mice reduces diet-induced hepatosteatosis and arteriosclerosis.

PloS one - 1 Jan 2013

Guo Wen, Wong Siu, Bhasin Shalender

Abstract excerpt

UNLABELLED: Genetic disruption of myostatin or its related signaling is known to cause strong protection against diet-induced metabolic disorders. The translational value of these prior findings, however, is dependent on whether such metabolically favorable phenotype can be reproduced when myostatin blockade begins at an adult age. Here, we reported that AAV-mediated delivery of a myostatin pro-peptide D76A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Arteriosclerosis
Share to Dependovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Liver

Share to Hep G2 Cells

Share to Myostatin

Share to Protein Precursors

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 23936482
DOI: 10.1371/journal.pone.0071017
PMCID: PMC3731267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AAV-mediated administration of myostatin pro-peptide mutant in adult Ldlr null mice reduces diet-induced hepatosteatosis and arteriosclerosis.PMID 23936482Read ↗

Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice.Semantic proximity Read ↗

Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic pathways, Inflammation, and AtherosclerosisSemantic proximity Read ↗

Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance.Semantic proximity Read ↗

Expression of myostatin pro domain results in muscular transgenic mice.Semantic proximity Read ↗

The aging myostatin null phenotype: reduced adiposity, cardiac hypertrophy, enhanced cardiac stress response, and sexual dimorphism.Semantic proximity Read ↗

Myostatin propeptide gene delivery by adeno-associated virus serotype 8 vectors enhances muscle growth and ameliorates dystrophic phenotypes in mdx mice.Semantic proximity Read ↗

Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis ResearchSemantic proximity Read ↗

A VLP-based immunogen that elicits selective anti-Myostatin antibodies, enhances muscle mass and strength, and reduces adipositySemantic proximity Read ↗

Cardiac-selective gene delivery of medium-chain acyl-CoA dehydrogenase (MCAD) does not protect against diabetes-induced cardiac dysfunctionSemantic proximity Read ↗

Angiotensinogen Exerts Effects Independent of Angiotensin II.Semantic proximity Read ↗

Mas receptor deficiency is associated with worsening of lipid profile and severe hepatic steatosis in ApoE-knockout mice.Semantic proximity Read ↗

Inhibition of in vitro and in vivo brown fat differentiation program by myostatin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.