Article
A burden of rare copy number variants in obsessive-compulsive disorder.
Molecular psychiatry - 1 Apr 2025
Halvorsen Matthew W, de Schipper Elles, Bäckman Julia, Strom Nora I, Hagen Kristen, Lindblad-Toh Kerstin, Karlsson Elinor K, Pedersen Nancy L, Wallert John, Bulik Cynthia M, Fundín Bengt, Landén Mikael, Kvale Gerd, Hansen Bjarne, Haavik Jan, Mattheisen Manuel, Rück Christian, Mataix-Cols David, Crowley James J
Abstract excerpt
Current genetic research on obsessive-compulsive disorder (OCD) supports contributions to risk specifically from common single nucleotide variants (SNVs), along with rare coding SNVs and small insertion-deletions (indels). The contribution to OCD risk from rare copy number variants (CNVs), however, has not been formally assessed at a similar scale. Here we describe an analysis of rare CNVs called from genotype...
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