Article
De novo mutations identified by whole-genome sequencing implicate chromatin modifications in obsessive-compulsive disorder.
Science advances - 14 Jan 2022
Lin Guan Ning, Song Weichen, Wang Weidi, Wang Pei, Yu Huan, Cai Wenxiang, Jiang Xue, Huang Wu, Qian Wei, Chen Yucan, Chen Miao, Yu Shunying, Xu Tingting, Jiao Yumei, Liu Qiang, Zhang Chen, Yi Zhenghui, Fan Qing, Chen Jue, Wang Zhen
Abstract excerpt
Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder with a substantial genetic basis and a broadly undiscovered etiology. Recent studies of de novo mutation (DNM) exome-sequencing studies for OCD have reinforced the hypothesis that rare variation contributes to the risk. We performed, to our knowledge, the first whole-genome sequencing on 53 parent-offspring families with offspring affected with OCD...
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