Article
Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways.
Translational psychiatry - 29 Mar 2016
Cappi C, Brentani H, Lima L, Sanders S J, Zai G, Diniz B J, Reis V N S, Hounie A G, Conceição do Rosário M, Mariani D, Requena G L, Puga R, Souza-Duran F L, Shavitt R G, Pauls D L, Miguel E C, Fernandez T V
Abstract excerpt
Studies of rare genetic variation have identified molecular pathways conferring risk for developmental neuropsychiatric disorders. To date, no published whole-exome sequencing studies have been reported in obsessive-compulsive disorder (OCD). We sequenced all the genome coding regions in 20 sporadic OCD cases and their unaffected parents to identify rare de novo (DN) single-nucleotide variants (SNVs). The primary...
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