Article

Atrial-Specific KCNQ1 Channelopathy Drives Arrhythmogenesis and Unmasks Amiodarone Proarrhythmia in a Human iPSC Model

2025-12-11

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : While KCNQ1 mutations (I <sub>Ks</sub> channel α-subunit) are known to cause long QT syndrome (LQTS) presenting with atrial fibrillation (AF), the underlying mechanisms remain incompletely characterized. <bold>Methods</bold> : We report a novel KCNQ1 c.625T>C (p.Ser209Pro) mutation identified through whole-exome sequencing and Sanger validation in a LQTS...

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Literature Corpus work: 4dd07269-af32-547d-8015-13938e13c7d7
DOI: 10.21203/rs.3.rs-8022975/v1

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