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Article

Patient-specific induced pluripotent stem-cell models for long-QT syndrome.

The New England journal of medicine - 7 Oct 2010

Moretti Alessandra, Bellin Milena, Welling Andrea, Jung Christian Billy, Lam Jason T, Bott-Flügel Lorenz, Dorn Tatjana, Goedel Alexander, Höhnke Christian, Hofmann Franz, Seyfarth Melchior, Sinnecker Daniel, Schömig Albert, Laugwitz Karl-Ludwig

Abstract excerpt

BACKGROUND: Long-QT syndromes are heritable diseases associated with prolongation of the QT interval on an electrocardiogram and a high risk of sudden cardiac death due to ventricular tachyarrhythmia. In long-QT syndrome type 1, mutations occur in the KCNQ1 gene, which encodes the repolarizing potassium channel mediating the delayed rectifier I(Ks) current. METHODS: We screened a family affected by long-QT...

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Source

Identifiers

PMID: 20660394
DOI: 10.1056/NEJMoa0908679

Genes

KCNQ1
KLF4
MYC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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