Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC–derived atrial fibrillation model

8 Apr 2022

Abstract excerpt

Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) can model heritable arrhythmias to personalize therapies for individual patients. Although atrial fibrillation (AF) is a leading cause of cardiovascular morbidity and mortality, current platforms to generate iPSC-atrial (a) CMs are inadequate for modeling AF. We applied a combinatorial engineering approach, which integrated multiple...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Neuroscience and Neural Engineering
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35393944
DOI: 10.1172/jci.insight.155640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC–derived atrial fibrillation modelPMID 35393944Read ↗

Atrial-Specific KCNQ1 Channelopathy Drives Arrhythmogenesis and Unmasks Amiodarone Proarrhythmia in a Human iPSC ModelSemantic proximity Read ↗

Single-Cell RNA-Sequencing and Optical Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Discordance Between Cardiac Subtype-Associated Gene Expression Patterns and Electrophysiological PhenotypesSemantic proximity Read ↗

Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for modeling cardiac arrhythmias: strengths, challenges and potential solutionsSemantic proximity Read ↗

Metabolically-Driven Maturation of hiPSC-Cell Derived Cardiac ChipSemantic proximity Read ↗

Human iPSC modelling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytesSemantic proximity Read ↗

Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation.Semantic proximity Read ↗

Metastable Atrial State Underlies the Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation.Semantic proximity Read ↗

Fibroblasts Drive Metabolic Reprogramming in Pacemaker CardiomyocytesSemantic proximity Read ↗

Dissecting the Molecular Mechanisms Driving Electropathology in Atrial Fibrillation: Deployment of RNA Sequencing and Transcriptomic AnalysesSemantic proximity Read ↗

Electrophysiological Phenotyping of hiPSC-Derived Atrial Cardiomyocytes Using Automated Patch-Clamp: A Platform for Studying Atrial Inherited Arrhythmias.Semantic proximity Read ↗

The molecular and functional identities of atrial cardiomyocytes in health and disease.Semantic proximity Read ↗

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.