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Article

Towards Mutation-Specific Precision Medicine in Atypical Clinical Phenotypes of Inherited Arrhythmia Syndromes.

International journal of molecular sciences - 10 Apr 2021

Nakajima Tadashi, Tamura Shuntaro, Kurabayashi Masahiko, Kaneko Yoshiaki

Abstract excerpt

Most causal genes for inherited arrhythmia syndromes (IASs) encode cardiac ion channel-related proteins. Genotype-phenotype studies and functional analyses of mutant genes, using heterologous expression systems and animal models, have revealed the pathophysiology of IASs and enabled, in part, the establishment of causal gene-specific precision medicine. Additionally, the utilization of induced pluripotent stem...

Topics

Arrhythmias, Cardiac
Atrial Fibrillation
Brugada Syndrome
Cardiac Electrophysiology
Death, Sudden, Cardiac
Humans
Long QT Syndrome
Phenotype
Precision Medicine

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Identifiers

PMID: 33920294
DOI: 10.3390/ijms22083930
PMCID: PMC8069124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-33920294-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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