Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Electrophysiological Phenotyping of hiPSC-Derived Atrial Cardiomyocytes Using Automated Patch-Clamp: A Platform for Studying Atrial Inherited Arrhythmias.

Cells - 6 Dec 2025

Jiménez-Sábado Verónica, Babini Hosna, Ruben Peter C, Accili Eric A, Claydon Thomas W, Hove-Madsen Leif, Tibbits Glen F

Abstract excerpt

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent a robust platform for modelling inherited cardiac disorders. Comparative analysis of ion channel activity in patient-specific and isogenic control lines provides critical insights into the molecular mechanisms underlying channelopathies and arrhythmias. Atrial-specific hiPSC-CMs (hiPSC-aCMs) exhibit distinct electrophysiological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophysiological Phenomena

Share to Heart Atria

Share to Induced Pluripotent Stem Cells

Share to Myocytes, Cardiac

Share to Patch-Clamp Techniques

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 41439960
DOI: 10.3390/cells14241941
PMCID: PMC12730866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Electrophysiological Phenotyping of hiPSC-Derived Atrial Cardiomyocytes Using Automated Patch-Clamp: A Platform for Studying Atrial Inherited Arrhythmias.PMID 41439960Read ↗

Ion channel expression and electrophysiology of singular human (primary and induced pluripotent stem cell derived) cardiomyocytesSemantic proximity Read ↗

Atrial-Specific KCNQ1 Channelopathy Drives Arrhythmogenesis and Unmasks Amiodarone Proarrhythmia in a Human iPSC ModelSemantic proximity Read ↗

Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell-Derived) CardiomyocytesSemantic proximity Read ↗

Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromesSemantic proximity Read ↗

Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as Models for Cardiac ChannelopathiesSemantic proximity Read ↗

Single-cell ionic current phenotyping elucidates non-canonical features and predictive potential of cardiomyocytes during automated drug experiments.Semantic proximity Read ↗

Single-Cell RNA-Sequencing and Optical Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Discordance Between Cardiac Subtype-Associated Gene Expression Patterns and Electrophysiological PhenotypesSemantic proximity Read ↗

Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and LimitationsSemantic proximity Read ↗

A novel ionic model for matured and paced atrial–like hiPSC–CMs integrating <i>I</i> <sub> <i>Kur</i> </sub> and <i>I</i> <sub> <i>KCa</i> </sub> currentsSemantic proximity Read ↗

Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for modeling cardiac arrhythmias: strengths, challenges and potential solutionsSemantic proximity Read ↗

Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by ElectrophysiologySemantic proximity Read ↗

Disrupted CaV1.2 selectivity causes overlapping long QT and Brugada syndrome phenotypes in the CACNA1C-E1115K iPS cell model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.