Article

Epistasis between drug resistance-conferring mutations in <i>Mycobacterium tuberculosis</i>

2025-08-07

Abstract excerpt

Studies in model organisms show that mutations conferring resistance to different antibiotics can interact epistatically, but the biological and epidemiological consequences of such interactions are unknown. Here we show that in Mycobacterium tuberculosis (Mtb) , positive sign epistasis between RpoB and GyrA mutations causing resistance to rifampicin and fluoroquinolone, respectively, can lead to double-resistant...

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Literature Corpus work: 4d97f309-1ea3-5852-ac89-c66e12a180ec
DOI: 10.1101/2025.08.07.669101

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