Article

Structure of mycobacterial NDH-2 bound to a 2-mercapto-quinazolinone inhibitor

2025-01-09

Abstract excerpt

The mycobacterial type II NADH dehydrogenase (NDH-2) is a promising drug target because of its central role in energy metabolism in Mycobacterium tuberculosis and other pathogens, and because it lacks a known mammalian homologue. However, the absence of structural information on how the enzyme binds inhibitors has made optimization of lead compounds challenging. We used electron cryomicroscopy (cryo-EM) to determ...

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Literature Corpus work: 4d9694e0-e954-5fa6-bb30-33e8a8fac28b
DOI: 10.1101/2025.01.08.631920

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Structure of mycobacterial NDH-2 bound to a 2-mercapto-quinazolinone inhibitorDOI 10.1101/2025.01.08.631920Read

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