Article
Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis.
Structure (London, England : 1993) - 5 Aug 2021
Munir Asma, Wilson Michael T, Hardwick Steven W, Chirgadze Dimitri Y, Worrall Jonathan A R, Blundell Tom L, Chaplin Amanda K
Abstract excerpt
Resolution advances in cryoelectron microscopy (cryo-EM) now offer the possibility to visualize structural effects of naturally occurring resistance mutations in proteins and also of understanding the binding mechanisms of small drug molecules. In Mycobacterium tuberculosis the multifunctional heme enzyme KatG is indispensable for activation of isoniazid (INH), a first-line pro-drug for treatment of tuberculosis....
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