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Article

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.

Science (New York, N.Y.) - 2 Jan 1998

Rozwarski D A, Grant G A, Barton D H, Jacobs W R, Sacchettini J C

Abstract excerpt

The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an enzyme essential for mycolic acid biosynthesis in Mycobacterium tuberculosis. Despite the widespread use of this drug for more than 40 years, its precise mode of action has remained obscure. Data from x-ray crystallography and mass spectrometry reveal that the mechanism of isoniazid action...

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Identifiers

PMID: 9417034
DOI: 10.1126/science.279.5347.98

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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