Article
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
Science (New York, N.Y.) - 2 Jan 1998
Rozwarski D A, Grant G A, Barton D H, Jacobs W R, Sacchettini J C
Abstract excerpt
The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an enzyme essential for mycolic acid biosynthesis in Mycobacterium tuberculosis. Despite the widespread use of this drug for more than 40 years, its precise mode of action ha...
Topics
- Antitubercular Agents
- Bacterial Proteins
- Binding Sites
- Biotransformation
- Crystallography, X-Ray
- Drug Resistance, Microbial
- Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
- Fatty Acid Synthases
- Isoniazid
- Mass Spectrometry
- Models, Molecular
- Mutation
- Mycobacterium tuberculosis
- Mycolic Acids
- NAD
- Oxidoreductases