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Article

Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.

ACS infectious diseases - 11 May 2018

Negri Ana, Javidnia Prisca, Mu Ran, Zhang Xiaojie, Vendome Jeremie, Gold Ben, Roberts Julia, Barman Dipti, Ioerger Thomas, Sacchettini James C, Jiang Xiuju, Burns-Huang Kristin, Warrier Thulasi, Ling Yan, Warren J David, Oren Deena A, Beuming Thijs, Wang Hongyao, Wu Jie, Li Haitao, Rhee Kyu Y, Nathan Carl F, Liu Gang, Somersan-Karakaya Selin

Abstract excerpt

The success of Mycobacterium tuberculosis (Mtb) as a pathogen depends on the redundant and complex mechanisms it has evolved for resisting nitrosative and oxidative stresses inflicted by host immunity. Improving our understanding of these defense pathways can reveal vulnerable points in Mtb pathogenesis. In this study, we combined genetic, structural, computational, biochemical, and biophysical approaches to...

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Identifiers

PMID: 29465985
DOI: 10.1021/acsinfecdis.7b00111
PMCID: PMC5952258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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