Article

Allosteric Regulation of Vitamin K2 Biosynthesis in a Human Pathogen

2019-11-14

Abstract excerpt

Menaquinone (Vitamin K2) plays a vital role in energy generation and environmental adaptation in many bacteria, including Mycobacterium tuberculosis ( Mtb ). Although menaquinone levels are known to be tightly linked to the redox/energy status of the cell, the regulatory mechanisms underpinning this phenomenon are unclear. The first committed step in menaquinone biosynthesis is catalyzed by MenD, a thiamine diph...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82eb8559-8c1d-5603-bfd5-c33384b3009c
DOI: 10.1101/841569

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Allosteric Regulation of Vitamin K2 Biosynthesis in a Human PathogenDOI 10.1101/841569Read

Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosisSemantic proximity Read

Apparent Reversal of Allosteric Response in Mycobacterium tuberculosis MenD Reveals Links to Half-of-Sites Reactivity.Semantic proximity Read

NAD+-targeting by bacteria: an emerging weapon in pathogenesisSemantic proximity Read

Partial Saturation of Menaquinone in <i>Mycobacterium tuberculosis</i>: Function and Essentiality of a Novel Reductase, MenJSemantic proximity Read

Rv3722c governs aspartate-dependent nitrogen metabolism in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Using substrate analogues to probe the kinetic mechanism and active site of Escherichia coli MenD.Semantic proximity Read

Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosisSemantic proximity Read

Uncovering the Roles of <i>Mycobacterium tuberculosis melH</i> in Redox and Bioenergetic Homeostasis: Implications for Antitubercular TherapySemantic proximity Read

Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexesSemantic proximity Read

AIM‐1: An Antibiotic‐Degrading Metallohydrolase That Displays Mechanistic FlexibilitySemantic proximity Read

Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis.Semantic proximity Read

Mycobacterium smegmatis msmeg_3314 is involved in pyrazinamide and fluoroquinolones susceptibility via NAD+/NADH dysregulation.Semantic proximity Read