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Article

Reversing Hepatocellular Carcinoma Progression by Using Networked Biological Therapies

1 Jan 2007

Abstract excerpt

The liver is distinguished from other tissues by (a) its detoxifying function, (b) its resistance to apoptosis, and (c) its regenerative response to damage. Hepatocellular carcinoma arises when chronic insults, such as hepatitis or iron overload, constitutively activate this regenerative program. Here, we propose that the proliferative response of the liver to damage underlies the resistance of hepatocellular...

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PMID: 17200333
DOI: 10.1158/1078-0432.ccr-06-1619

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