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Article

Clock gene Per2 as a controller of liver carcinogenesis.

Oncotarget - 27 Dec 2016

Mteyrek Ali, Filipski Elisabeth, Guettier Catherine, Okyar Alper, Lévi Francis

Abstract excerpt

Environmental disruption of molecular clocks promoted liver carcinogenesis and accelerated cancer progression in rodents. We investigated the specific role of clock gene Period 2 (Per2) for liver carcinogenesis and clock-controlled cellular proliferation, genomic instability and inflammation. We assessed liver histopathology, and determined molecular and physiology circadian patterns in mice on chronic...

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Identifiers

PMID: 27494874
DOI: 10.18632/oncotarget.11037
PMCID: PMC5349878

Genes

ATM
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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