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Article

Structure, evolution, and inhibitor interaction of S‐adenosyl‐ L ‐homocysteine hydrolase from Plasmodium falciparum

1 Aug 2003

Abstract excerpt

S-adenosylhomocysteine hydrolase (SAHH) is a key regulator of S-adenosylmethionine-dependent methylation reactions and an interesting pharmacologic target. We cloned the SAHH gene from Plasmodium falciparum (PfSAHH), with an amino acid sequence agreeing with that of the PlasmoDB genomic database. Even though the expressed recombinant enzyme, PfSAHH, could use 3-deaza-adenosine (DZA) as an alternative substrate in...

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PMID: 12910461
DOI: 10.1002/prot.10446

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