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Article

Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.

Nature - 10 Dec 2009

Guo Min, Chong Yeeting E, Shapiro Ryan, Beebe Kirk, Yang Xiang-Lei, Schimmel Paul

Abstract excerpt

Mistranslation arising from confusion of serine for alanine by alanyl-tRNA synthetases (AlaRSs) has profound functional consequences. Throughout evolution, two editing checkpoints prevent disease-causing mistranslation from confusing glycine or serine for alanine at the active site of AlaRS. In both bacteria and mice, Ser poses a bigger challenge than Gly. One checkpoint is the AlaRS editing centre, and the other...

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Identifiers

PMID: 20010690
DOI: 10.1038/nature08612
PMCID: PMC2799227

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