Article

The autophagy inducer SMER28 attenuates microtubule dynamics mediating neuroprotection

2022-03-23

Abstract excerpt

SMER28 was originally identified in a screen for small-molecules that act as modulators of autophagy. SMER28 enhanced the clearance of autophagic substrates such as mutant huntingtin, an effect that was independent of rapamycin-induced autophagy. Thus, SMER 28 was established as a positive regulator of autophagy acting independently of the mTOR pathway, increasing autophagosome biosynthesis and attenuating mutant...

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Literature Corpus work: 4d444468-d209-5b1a-ae1a-5250211449b6
DOI: 10.21203/rs.3.rs-1361340/v1

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