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Comparative analysis of two autophagy-enhancing small molecules (AUTEN-67 and -99) in a <i>Drosophila</i> model of Spinocerebellar ataxia type 1

2025-09-20

Abstract excerpt

Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells which is critical for the elimination of cellular damage. Its capacity progressively declines with age, and this change can lead to the development of various neurodegenerative pathologies including Spinocerebellar ataxia type 1 (SCA1). SCA1 is mainly caused by mutations in the polyglutamine region of Ataxin 1 protein. In patients affect...

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Literature Corpus work
518b38c2-f970-5619-94a5-48a60db63da0
DOI
10.1101/2025.09.18.677017
Open publication

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