Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells.

Neuroscience letters - 12 Mar 2010

Dadakhujaev Shorafidinkhuja, Noh Hae Sook, Jung Eun Joo, Cha Joon Yung, Baek Seon Mi, Ha Ji Hye, Kim Deok Ryong

Abstract excerpt

Loss of dopaminergic cells induced by alpha-synuclein accumulation in substantia nigra causes the development of Parkinson's disease (PD). To date, although autophagy has been implicated in the pathology of PD, the molecular mechanism is still unclear. To study the role of autophagy in PD pathogenesis, we established stable SH-SY5Y cell lines overexpressing wild-type or mutant alpha-synuclein proteins (A30P or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Death

Share to Cell Line

Share to Dopamine

Share to Membrane Potential, Mitochondrial

Share to Microtubule-Associated Proteins

Share to Rotenone

Source

Identifiers

PMID: 20117172
DOI: 10.1016/j.neulet.2010.01.053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells.PMID 20117172Read ↗

The autophagy–lysosome pathway: a potential target in the chemical and gene therapeutic strategies for Parkinson’s diseaseSemantic proximity Read ↗

Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synucleinSemantic proximity Read ↗

The Parkinson disease protein α-synuclein inhibits autophagySemantic proximity Read ↗

Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)Semantic proximity Read ↗

Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of AutophagySemantic proximity Read ↗

Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein.Semantic proximity Read ↗

Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein.Semantic proximity Read ↗

Melatonin prevents dopaminergic cell loss induced by lentiviral vectors expressing A30P mutant alpha-synuclein.Semantic proximity Read ↗

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.Semantic proximity Read ↗

Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats.Semantic proximity Read ↗

p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's diseaseSemantic proximity Read ↗

Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.