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Article

Regulation of presynaptic neurotransmission by macroautophagy.

Neuron - 26 Apr 2012

Hernandez Daniela, Torres Ciara A, Setlik Wanda, Cebrián Carolina, Mosharov Eugene V, Tang Guomei, Cheng Hsiao-Chun, Kholodilov Nikolai, Yarygina Olga, Burke Robert E, Gershon Michael, Sulzer David

Abstract excerpt

mTOR is a regulator of cell growth and survival, protein synthesis-dependent synaptic plasticity, and autophagic degradation of cellular components. When triggered by mTOR inactivation, macroautophagy degrades long-lived proteins and organelles via sequestration into autophagic vacuoles. mTOR further regulates synaptic plasticity, and neurodegeneration occurs when macroautophagy is deficient. It is nevertheless...

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Identifiers

PMID: 22542182
DOI: 10.1016/j.neuron.2012.02.020
PMCID: PMC3578406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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