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Article

ROCK inhibition in models of neurodegeneration and its potential for clinical translation

3 Apr 2018

Abstract excerpt

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic lateral sclerosis are affecting a rapidly increasing population worldwide. While common pathomechanisms such as protein aggregation, axonal degeneration, dysfunction of protein clearing and an altered immune response have been characterized, no disease-modifying therapies have been developed so far. Interestingly, a...

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PMID: 29621594
DOI: 10.1016/j.pharmthera.2018.03.008

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