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Article

A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

Cell stem cell - 6 Jun 2013

Yang Yin M, Gupta Shailesh K, Kim Kevin J, Powers Berit E, Cerqueira Antonio, Wainger Brian J, Ngo Hien D, Rosowski Kathryn A, Schein Pamela A, Ackeifi Courtney A, Arvanites Anthony C, Davidow Lance S, Woolf Clifford J, Rubin Lee L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, characterized by motor neuron (MN) death, for which there are no truly effective treatments. Here, we describe a new small molecule survival screen carried out using MNs from both wild-type and mutant SOD1 mouse embryonic stem cells. Among the hits we found, kenpaullone had a particularly impressive ability to prolong the...

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Identifiers

PMID: 23602540
DOI: 10.1016/j.stem.2013.04.003
PMCID: PMC3707511

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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