Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-autonomy of age-related morphological changes in the C. elegans germline stem cell niche.

Development (Cambridge, England) - 15 Oct 2025

Gupta Nilay, Sinks Mia, Hubbard E Jane Albert

Abstract excerpt

Declines in tissue renewal and repair due to alterations in tissue stem cells is a hallmark of aging. Many stem cell pools are maintained by morphologically complex niches. Using the C. elegans hermaphrodite germline stem cell system, we analyzed age-related changes in the morphology of the niche, the distal tip cell (DTC), and identified a molecular mechanism that promotes a subset of these changes. We found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Germ Cells

Share to Receptor, Insulin

Share to Stem Cell Niche

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 41127995
DOI: 10.1242/dev.204970
PMCID: PMC12582414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-autonomy of age-related morphological changes in the C. elegans germline stem cell niche.PMID 41127995Read ↗

Progression from a stem cell-like state to early differentiation in the C. elegans germ line.Semantic proximity Read ↗

Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.Semantic proximity Read ↗

Rapid, population-wide declines in stem cell number and activity during reproductive aging in C. elegansSemantic proximity Read ↗

Germline stem cell maintenance as a proximate mechanism of life-history trade-offs? Drosophila selected for prolonged fecundity have a slower rate of germline stem cell loss.Semantic proximity Read ↗

C. elegans germline stem cells and their nicheSemantic proximity Read ↗

Non-autonomous PMK-1/p38 MAPK signaling ensures homeostatic downregulation of germline stem cell proliferation in <i>C. elegans</i>Semantic proximity Read ↗

Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cellsSemantic proximity Read ↗

Cell cycle features of C. elegans germline stem/progenitor cells vary temporally and spatially.Semantic proximity Read ↗

C. elegans germ cells divide and differentiate in a folded tissueSemantic proximity Read ↗

A DTC Niche Plexus Surrounds the Germline Stem Cell Pool in Caenorhabditis elegansSemantic proximity Read ↗

When stem cells grow old: phenotypes and mechanisms of stem cell agingSemantic proximity Read ↗

<i>Caenorhabditis elegans</i> as a model for stem cell biologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.