<i>mab-2</i>encodes RNT-1, a<i>C. elegans</i>Runx homologue essential for controlling cell proliferation in a stem cell-like developmental lineage

Abstract excerpt

In this report, we demonstrate that C. elegans mab-2 mutants have defects in the development of a male-specific sense organ because of a failure in the proliferation of the stem cell-like lateral hypodermal (seam) cells. We show, by positional cloning, that mab-2 encodes RNT-1, the only C. elegans member of the Runx family of transcriptional regulators, which are postulated to act both as oncogenes and tumour...

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