Article
p53 gain-of-function mutations increase Cdc7-dependent replication initiation.
EMBO reports - 1 Nov 2017
Datta Arindam, Ghatak Dishari, Das Sumit, Banerjee Taraswi, Paul Anindita, Butti Ramesh, Gorain Mahadeo, Ghuwalewala Sangeeta, Roychowdhury Anirban, Alam Sk Kayum, Das Pijush, Chatterjee Raghunath, Dasgupta Maitrayee, Panda Chinmay Kumar, Kundu Gopal C, Roychoudhury Susanta
Abstract excerpt
Cancer-associated p53 missense mutants confer gain of function (GOF) and promote tumorigenesis by regulating crucial signaling pathways. However, the role of GOF mutant p53 in regulating DNA replication, a commonly altered pathway in cancer, is less explored. Here, we show that enhanced Cdc7-dependent replication initiation enables mutant p53 to confer oncogenic phenotypes. We demonstrate that mutant p53...
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