Article

Validation of an RNase H2 activity assay suitable for clinical screening

2022-06-10

Abstract excerpt

As the key enzyme mediating ribonucleotide excision repair, RNase H2 is essential for the removal of single ribonucleotides from DNA in order to prevent genome damage. Loss of RNase H2 activity directly contributes to the pathogenesis of autoinflammatory and autoimmune diseases and might further play a role in ageing and neurodegeneration. Moreover, RNase H2 activity is a potential diagnostic and prognostic marker...

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Literature Corpus work: 4d1f117e-c682-565a-85b2-bd3c37cdc7ac
DOI: 10.1101/2022.06.09.494809

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