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Article

Ribonuclease H2 in health and disease

1 Aug 2014

Abstract excerpt

Innate immune sensing of nucleic acids provides resistance against viral infection and is important in the aetiology of autoimmune diseases. AGS (Aicardi-Goutières syndrome) is a monogenic autoinflammatory disorder mimicking in utero viral infection of the brain. Phenotypically and immunologically, it also exhibits similarities to SLE (systemic lupus erythaematosus). Three of the six genes identified to date...

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PMID: 25109948
DOI: 10.1042/bst20140079

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