Article

Comprehensive Measurement of Inter-Individual Variation in DNA Repair Capacity in Healthy Individuals

2025-06-16

Abstract excerpt

Rare genetic DNA repair deficiency syndromes can lead to immunodeficiency, neurological disorders, and cancer. In the general population, inter-individual variation in DNA repair capacity (DRC) influences susceptibility to cancer and several age-related diseases. Genome wide association studies and functional analyses show that defects in multiple DNA repair pathways jointly increase disease risk, but previous tec...

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Literature Corpus work: 1fbde210-917d-5169-ab29-d7552a684a00
DOI: 10.1101/2025.06.13.25329369

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