Article

High glucose promotes macrophage switching to M1 phenotype via down-regulating STAT-3 mediated- autophagy

2023-02-16

Abstract excerpt

<h4>Aim: </h4> Imbalance of M1/M2 macrophages phenotype activation is a key point in diabetic kidney disease (DKD). Macrophages mainly exhibit M1 phenotype, which contributes to the inflammation and fibrosis in DKD. Studies indicate that autophagy plays an important role in M1/M2 activation. However, the mechanism of autophagy regulating macrophage M1/M2 phenotype in DKD is unknown. Thus, the aim of this study is...

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Literature Corpus work: 4d138d3f-ea0c-5b33-a4b5-4b8b1a9378ec
DOI: 10.21203/rs.3.rs-2581231/v1

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