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Article

Mitophagy regulates macrophage phenotype in diabetic nephropathy rats.

Biochemical and biophysical research communications - 9 Dec 2017

Zhao Yu, Guo Yinfeng, Jiang Yuteng, Zhu Xiaodong, Liu Yuqiu, Zhang Xiaoliang

Abstract excerpt

Imbalance of M1/M2 macrophages phenotype activation is a key point in diabetic nephropathy (DN). Macrophages mainly exhibit M1 phenotype, which contributes to the inflammation and fibrosis in DN. Studies indicate that autophage plays an important role in M1/M2 activation. However, the effect of mitophage on M1/M2 macrophage phenotype transformation in DN is unknown. This study investigates the role of mitophage...

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Share to Autophagy
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetic Nephropathies

Share to Microscopy, Electron, Transmission

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Share to Nitric Oxide Synthase Type II

Share to Rats, Sprague-Dawley

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Source

Identifiers

PMID: 29061302
DOI: 10.1016/j.bbrc.2017.10.088

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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