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Article

High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy.

PloS one - 1 Jan 2024

Zhao Yu, Jiang Yuteng, Wang Fengmei, Sun Li, Ding Mengyuan, Zhang Liyuan, Wu Beibei, Zhang Xiaoliang

Abstract excerpt

AIM: Imbalanced M1/M2 macrophage phenotype activation is a key point in diabetic kidney disease (DKD). Macrophages mainly exhibit the M1 phenotype, which contributes to inflammation and fibrosis in DKD. Studies have indicated that autophagy plays an important role in M1/M2 activation. However, the mechanism by which autophagy regulates the macrophage M1/M2 phenotype in DKD is unknown. Thus, the aim of the present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39739966
DOI: 10.1371/journal.pone.0314974
PMCID: PMC11687880

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