Article

Allosteric site variants affect GTP hydrolysis on RAS

2023-05-29

Abstract excerpt

<h4> Abstract </h4> RAS GTPases are proto-oncoproteins that regulate cell growth, proliferation, and differentiation in response to extracellular signals. The signaling functions of RAS, and other small GTPases, are dependent on their ability to cycle between GDP-bound and GTP-bound states. Structural analyses suggest that GTP hydrolysis catalyzed by HRAS can be regulated by an allosteric site located between he...

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Literature Corpus work: 4d0c97fd-b518-51d2-a2de-41b7e3cd91e6
DOI: 10.1101/2023.05.29.542740

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