The Neomorphic Chemistry of KRAS Autophosphorylation Is Dynamically Regulated by Active Site Conformation.

Abstract excerpt

Small GTPases function as binary switches, taking on different functional states depending on whether they are bound to GTP or GDP. Maintenance of these nucleotide-dependent states at a cellular level is accomplished through the action of different regulatory proteins, which function to either increase nucleotide exchange, suppress nucleotide exchange, or catalyze GTP hydrolysis. For the small GTPases KRAS, NRAS,...

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