Article

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

2020-06-05

Abstract excerpt

<h4>ABSTRACT</h4> RAS mutations are the most common oncogenic drivers across human cancers, but there remains a paucity of clinically-validated pharmacological inhibitors of RAS, as druggable pockets have proven difficult to identify. We have identified two RAS-binding Affimer proteins, K3 and K6, that inhibit nucleotide exchange and downstream signalling pathways with distinct isoform and mutant profiles. Affime...

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Literature Corpus work: 12038602-83c7-5c0d-a786-5e7676ea079b
DOI: 10.1101/2020.06.04.133728

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