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Article

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.

The Journal of biological chemistry - 27 Nov 2015

Lu Shaoyong, Banerjee Avik, Jang Hyunbum, Zhang Jian, Gaponenko Vadim, Nussinov Ruth

Abstract excerpt

K-Ras4B, a frequently mutated oncogene in cancer, plays an essential role in cell growth, differentiation, and survival. Its C-terminal membrane-associated hypervariable region (HVR) is required for full biological activity. In the active GTP-bound state, the HVR interacts with acidic plasma membrane (PM) headgroups, whereas the farnesyl anchors in the membrane; in the inactive GDP-bound state, the HVR may...

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Identifiers

PMID: 26453300
DOI: 10.1074/jbc.M115.664755
PMCID: PMC4661403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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