Article

Defining An Expanded RAS Conformational Landscape Based on Over 700 Experimentally Determined Structures of KRAS, NRAS, and HRAS

2022-02-05

Abstract excerpt

<h4>ABSTRACT</h4> For many human cancers and tumor-associated diseases, mutations in the RAS isoforms (KRAS, NRAS, and HRAS) are the most common oncogenic alterations, making these proteins high-priority therapeutic targets. Effectively targeting the RAS isoforms requires an exact understanding of their active, inactive, and druggable conformations. However, there is no structure-guided catalogue of RAS conformat...

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Literature Corpus work: 1b08063d-a099-5ab2-b2cb-36c1ce493a38
DOI: 10.1101/2022.02.02.478568

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