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Article

Mechanisms of isoform-specific residue influence on GTP-bound HRas, KRas, and NRas.

Biophysical journal - 4 Oct 2022

Volmar Alicia Y, Guterres Hugo, Zhou Hao, Reid Derion, Pavlopoulos Spiro, Makowski Lee, Mattos Carla

Abstract excerpt

HRas, KRas, and NRas are GTPases with a common set of effectors that control many cell-signaling pathways, including proliferation through Raf kinase. Their G-domains are nearly identical in sequence, with a few isoform-specific residues that have an effect on dynamics and biochemical properties. Here, we use accelerated molecular dynamics (aMD) simulations consistent with solution x-ray scattering experiments to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35794829
DOI: 10.1016/j.bpj.2022.07.005
PMCID: PMC9617160

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