Article

Deciphering the mechanism of protein aggregation and effects of inhibitors using single-molecule mass photometry

2025-08-13

Abstract excerpt

Aggregation of misfolded proteins is a prominent feature of many diseases and hence an attractive drug target. However, the small oligomers that are critical early species in the aggregation cascade are difficult to monitor directly owing to their heterogeneity and transience, complicating efforts to define aggregation mechanisms and target oligomers therapeutically. Here, we observe changes in oligomer population...

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Literature Corpus work: c2a2a137-cb4b-5a38-bae8-41125786931a
DOI: 10.1101/2025.08.11.668757

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