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Article

A Pan-Cancer Analysis of SMARCA4 Alterations in Human Cancers.

Frontiers in immunology - 1 Jan 2021

Peng Ling, Li Jisheng, Wu Jie, Xu Bin, Wang Zhiqiang, Giamas Georgios, Stebbing Justin, Yu Zhentao

Abstract excerpt

Background: SMARCA4, the essential ATPase subunit of SWI/SNF chromatin remodeling complex, regulates transcription through the control of chromatin structure and is increasingly thought to play significant roles in human cancers. This study aims to explore the potential role of SMARCA4 with a view to providing insights on pathologic mechanisms implicated here. Methods: The potential roles of SMARCA4 in different...

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Identifiers

PMID: 34675941
DOI: 10.3389/fimmu.2021.762598
PMCID: PMC8524462

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