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Article

Mutation of SMARCA4 Induces Cancer Cell-Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy.

Cancer research - 2 Jun 2025

Wang Yawen, Meraz Ismail M, Qudratullah Md, Kotagiri Sasikumar, Han Yanyan, Xi Yuanxin, Wang Jing, Akdemir Kadir C, Roth Jack A, Lissanu Yonathan

Abstract excerpt

Cancer genomic studies have identified frequent alterations in genes encoding components of the SWI/SNF chromatin remodeling complex, including SMARCA4 and ARID1A. Importantly, clinical reports indicate that SMARCA4-mutant lung cancers respond poorly to immunotherapy and have dismal prognosis. In this study, we corroborated the clinical findings by using immune-humanized, syngeneic, and genetically engineered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40080526
DOI: 10.1158/0008-5472.CAN-24-2054
PMCID: PMC12127800

Genes

SMARCA4
STING1
ARID1A
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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